It's just not typos that bother me. Italics bug me, too. More so, actually, because italics in a novel are done purposefully to make a point.
I'm reading a Patterson book right now, and it's riddled with italics. There are probably five or six italicized words and phrases on every single page. It's beyond distracting. Does Patterson not trust his readers to understand the point he's trying to make?
Italics are like a spice. Used sparingly, they can certainly enhance what the author is trying to say. Used in excess, the dish is ruined.